Nature's Way Protective Breast Formula supports balanced estrogen metabolism. It's formulated by Christine Horner, MD, FACS, and contains the clinically studied Indolplex BR-DIM. This product promotes a beneficial ratio of estrogens and supports premenstrual breast comfort. Formulated with calcium D-glucarate, vitamin D3, green tea extract, and more. Indolplex and BR-DIM is a proprietary, enhanced bioavailability complex containing Diindolylmethane licensed from BioResponse, LLC., Boulder, CO.