NutraLife The Original SAMe™ features a whopping 400 mg of active SAMe (s-adenosyl methionine) in each enteric coated tablet. SAMe is a nutrient that is naturally synthesized in the body and is involved in over 40 biochemical reactions, some of which support liver and joint health, as well providing support for a positive mood. Contains no peanuts, eggs, dairy, soy, wheat, yeast, gluten, tree nuts, crustacean shellfish, fish or other animal byproducts.